Integrative Ayurvedic Management of severe Globozoospermia with long-standing Male Infertility: A Case Report

Abstract

Male factor infertility contributes significantly to delayed conception, with complex

etiologies such as severe sperm morphological defects posing major therapeutic challenges. Globozoospermia, a rare form of Teratozoospermia characterized by round-headed sperm lacking acrosomes, is associated with poor fertilization outcomes. Conventional management options are limited, particularly in long- standing and treatment-refractory cases. Ayurveda describes male infertility under the spectrum of Ksheena sukra and emphasizes Shodhana, Shamana, and Rasayana therapies for restoration of reproductive health. A 48-year-old male with 18 years of primary infertility presented after unsuccessful conventional treatments, including varicocelectomy, 16 intrauterine inseminations, and one in vitro fertilization resulting in mid-trimester miscarriage. His history included childhood mumps. Semen analysis revealed hypospermia with astheno-teratozoospermia and severe globozoospermia, with less than 1% normal sperm morphology. He underwent a comprehensive Ayurvedic treatment protocol comprising internal medications and sequential Panchakarma procedures, including Takradhara, Udwarthana, Snehapana, Virechana, Jalookavacharana, Yoga Vasti, and RajayapanaBasti, along with Rasayana therapy, over a period of approximately two and half months. Post-treatment semen analysis showed remarkable improvement: sperm concentration increased from 25 million/ml to 224 million/ml, progressive motility improved from 25% to 35%, and normal morphology rose from less than 1% to over 70%. The patient also reported better sleep and overall well-being. This case highlights the potential of integrative Ayurvedic management in severe male infertility conditions like globozoospermia, warranting further systematic research to validate these findings.